Computationally Uncovering Protein Roles

While we now know the sequence of many organisms (including mice and humans) we still know relatively little about the roles played by the genes and proteins encoded within these sequences. Researchers have generated a great deal of data that can potentially shed light on to the functions and processes performed by proteins, however, these datasets are generally noisy, heterogeneous, and very large. Our group develops and applies machine learning and data mining techniques to these data that overcome these challenges in order to form highly confident predictions of protein roles. We then take these predictions back to the lab bench with our collaborators to confirm their validity.

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