Discovery of biological networks from diverse functional genomic data

Publication Type  Journal Article
Author  Myers CL, Robson D, Wible A, Hibbs MA, Chiriac C, Theesfeld CL, Dolinski K, Troyanskaya OG
Year of Publication  2005
Journal  Genome Biology
Volume  6
Issue  13
Pagination  R114
Date Published  Jan
Publication Language  eng
Abstract  

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.

URL  http://genomebiology.com/2005/6/13/R114
Citation Key  Myers:2005p275